MOLECULAR NETWORK ANALYSIS SUGGESTS A LOGICAL HYPOTHESIS FOR THE PATHOLOGICAL ROLE OF C9ORF72 IN AMYOTROPHIC LATERAL SCLEROSIS/FRONTOTEMPORAL DEMENTIA

Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (abbreviated as C9AL

Friction Stir Welding (FSW) has the advantage of Gift Card generating sound welds on materials that generally present low weldability by traditional fusion welding processes, such as 2xxx and 7xxx aluminum alloys.Force measurement in FSW provides significant information about the process, the machine requirements, the effect of selected parameters,

Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis in humans.Many of these mutations are known Stationery to have a gain-of-function effect on the non-specific cation channel function of TRPC6.In vitro studies have suggested these mutations affect several signaling pathways, but in vivo studies have largely comp

The development and utilization of wave energy is inseparable from the wave energy converter, and its stability is an important condition for operation.Heave is the biggest factor affecting the stable power generation of wave energy converters.The key method to solve this problem is to install a suitable heave plate.Therefore, the design of the hea

AbstractThis work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf.extract tablet.Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried console front rice starch, and spray-dried lactose were used.MCC exhibited superior performance to the other diluents by providing the hardest tablet, the lowest friability